Pharm D 1st Year Organic Chemistry Unit 11 PDF Notes

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Get ready, pharmacy students, as Pharm D Organic Chemistry Unit 11 PDF Notes dives into the world of nucleophilic addition reactions! We’ll explore the mechanism behind these fascinating reactions, where a nucleophile forms a new bond with the carbonyl carbon of a carboxylic acid. Buckle up as we delve into the ionization of carboxylic acids, understanding their acidity constants and how substituent groups can influence their acidic strength. We’ll then conquer nucleophilic acyl substitution reactions, the workhorses behind converting carboxylic acids to various derivatives like acid chlorides, esters, amides, and anhydrides. Throughout this journey, we’ll compare and contrast alkyl nucleophilic substitution with acyl nucleophilic substitution, uncovering the key differences between these two reaction types. So, pharmacy students, prepare to unlock the secrets of nucleophilic addition and witness its power in transforming carboxylic acids in Pharm D Organic chemistry PDF Notes!

Pharm D Organic Chemistry Unit 11 PDF Notes

Unit 11

Nucleophilic addition reaction: Mechanism, ionization of carboxylic acids, acidity constants, acidity of acids, structure of carboxylate ions, effect of substituent on acidity, nucleophilic acyl substitution reaction, conversion of acid to acid chloride, esters, amide and anhydride. Role of carboxyl group, comparison of alkyl nucleophilic substitution with acyl nucleophilic substitution.